Open Targets Platform: supporting systematic drug–target identification and prioritisation
نویسندگان
چکیده
منابع مشابه
Open Targets: a platform for therapeutic target identification and validation
We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The pla...
متن کاملUrban Open Spaces Supporting Physical Activity and Promoting Citizen’s Health: A Systematic Review
Background and Objective: Due to the limited individual approach to behavior change, health promotion researchers use community-based initiatives to understand the factors affecting physical activity and promote the health of citizens. Urban open spaces can facilitate participation in physical activity and the health of citizens. The aim of this study is to identify the indicators, attributes, ...
متن کاملLiterature evidence in open targets - a target validation platform
BACKGROUND We present the Europe PMC literature component of Open Targets - a target validation platform that integrates various evidence to aid drug target identification and validation. The component identifies target-disease associations in documents and ranks the documents based on their confidence from the Europe PMC literature database, by using rules utilising expert-provided heuristic i...
متن کاملSystematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens.
Phenotypic drug discovery offers some advantages over target-based methods, mainly because it allows drug leads to be tested in systems that more closely model distinct disease states. However, a potential disadvantage is the difficulty of linking the observed phenotype to a specific cellular target. To address this problem, we developed DePick, a computational target de-convolution tool to det...
متن کاملSystematic and Open Identification of Researchers and Authors: Focus on Open Researcher and Contributor ID
Unique identifiers of researchers and authors can help all stakeholders of scientific communications improve their workflows. There have been several attempts to establish professional networks of scholars and list their scholarly achievements on digital platforms. Some of these platforms such as Google Scholar, Web of Knowledge and PubMed are searched to pick relevant peer reviewers, assess au...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2020
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkaa1027